Cagrilintide is a synthetic reference peptide analog of amylin with an added eicosanoic (C20 diacid) side chain allowing albumin binding. It is described in published literature as an agonist of heterodimeric amylin receptor complexes AMY1-3 (calcitonin receptor in combination with RAMPs).
Investigated biochemical pathways (academic context)
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AMY1-3 receptor agonism: in-vitro binding assays on cloned AMY receptor complexes.
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Receptor pharmacology: characterization of signaling cascades in isolated cell models.
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Academic research area: referenced in studies of energy homeostasis regulation within the research area of metabolic diseases.
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Extended pharmacokinetics: in-vitro models of albumin binding as a subject of pharmacokinetic research.
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Combination studies: academic interest in synergy with GLP-1 agonists (e.g., the so-called CagriSema combination) at the level of in-vitro models.
Laboratory use and storage
Suitable as a reference standard for HPLC and in-vitro receptor assays. In laboratory practice, lyophilized peptides are handled using appropriate sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as Bacteriostatic Water - 10 ml. Store lyophilized material at -20 °C, protected from light.
Product purpose
This material is sold exclusively as a reference standard for laboratory and in-vitro research, biochemical analysis, and educational purposes. It is not intended for human consumption, therapeutic use, topical application, ingestion, inhalation, or veterinary purposes. It is not a medicine, dietary supplement, cosmetic, or medical device.
Access
Sales are subject to confirmation of age 18+ and declaration of research or collection purpose upon order completion.
Storage and handling
In laboratory practice, lyophilized peptides are handled using appropriate sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as Bacteriostatic Water - 10 ml. To maintain the stability of the material's structure, cold storage and protection from light are recommended.
