TB-500 is a synthetic peptide sequence corresponding to the protein Thymosin Beta-4 (Tβ4), supplied as a reference lyophilized standard of the highest purity (≥ 98% HPLC). In biochemical studies, Tβ4 is referenced as the main intracellular G-actin sequestering protein, making TB-500 a significant subject of academic research into cytoskeletal dynamics.
Due to its relatively low molecular weight and diffusion properties, TB-500 is a key reference material in in-vitro experiments focusing on cell migration, endothelial proliferation, and modulation of the inflammatory cascade at the isolated cell level.
Investigated Biochemical Pathways (Academic Context)
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Regulation of G-actin and cell motility: binding interaction with monomeric actin in in-vitro models of keratinocytes and fibroblasts; cytoskeleton reorganization.
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Endothelial assays: in-vitro models of tube formation and endothelial cell proliferation; tissue models with low natural perfusion (bradytrophic models).
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Cytokine modulation: in-vitro models of interaction with pro-inflammatory mediators and monitoring of oxidative stress at the cellular level.
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Differentiation of progenitor cells: investigation of the activation of tissue progenitor populations in controlled cell models.
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Cardiomyocyte and neural in-vitro models: academic research into interaction with mitochondrial membranes in ischemia-reperfusion models and remyelination models in isolated nerve cultures.
Laboratory Use and Storage
The lyophilized powder is suitable as a reference standard for HPLC, mass spectrometry, and binding assays. In laboratory practice, lyophilized peptides are handled using suitable sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as Bacteriostatic Water - 10 ml. To maintain the stability of the material's structure, storage in a cool place and protection from light are recommended.
Product Purpose
This material is sold exclusively as a reference standard for laboratory and in-vitro research, biochemical analysis, and educational purposes. It is not intended for human consumption, therapeutic use, skin application, ingestion, inhalation, or veterinary purposes. It is not a drug, dietary supplement, cosmetic, or medical device.
Access
Sales are subject to confirmation of age 18+ and declaration of research or collector's purpose upon completion of the order.
