PT-141 (Bremelanotide) is a reference synthetic cyclic peptide derived from α-MSH (α-melanocyte stimulating hormone). Its cyclic structure (disulfide bridge) increases its resistance to enzymatic degradation compared to linear analogs, making it a stable subject for in-vitro receptor studies.
Investigated biochemical pathways (academic context)
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Melanocortin receptor activation: in-vitro binding assays on cloned MC1R, MC3R, MC4R, and MC5R; affinity to MC4R expressed in hypothalamic cell lines.
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CNS pathway investigation: in-vitro models of interaction with dopaminergic and oxytocinergic signaling systems in isolated neuronal cultures.
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Neuroendocrine academic research: referenced in studies of the melanocortin system in the context of energy homeostasis and inflammatory responses at the cellular model level.
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Structural stability: characterization of the conformational stability of the cyclic peptide by HPLC and MS methods.
Laboratory use and storage
Suitable as a reference standard for HPLC, MS, and in-vitro receptor assays. In laboratory practice, lyophilized peptides are handled using appropriate sterile media. A compatible solvent intended exclusively for research purposes can be found in our offer as Bacteriostatic Water - 10 ml. Store the lyophilized powder at -20 °C, protected from light.
Product purpose
This material is sold exclusively as a reference standard for laboratory and in-vitro research, biochemical analysis, and educational purposes. It is not intended for human consumption, therapeutic use, skin application, ingestion, inhalation, or veterinary purposes. It is not a drug, dietary supplement, cosmetic, or medical device.
Access
Sales are subject to age verification 18+ and a declaration of research or collector's purpose upon completion of the order.
